Acamprosate is another popular choice for people with moderate to severe alcohol use disorder (AUD). It’s FDA-approved and often used instead of naltrexone for people who can’t take naltrexone, such as those of us with liver problems or who use opioids. The goal of the Sinclair Method is for the person to willingly change their drinking habits instead of trying to quit drinking cold turkey.

Toxic Positivity vs. Healthy Optimism
If you stop taking naltrexone and drink alcohol, your brain will likely begin to re-learn the connection between drinking and pleasure, potentially undoing progress. It’s important to follow the protocol consistently, it’s called “the Golden Rule” for a very good reason. Yes, naltrexone is a prescription medication, and you’ll need to consult a healthcare provider to determine if it’s appropriate for you. Thrive has partnered with specialized physicians across all 50 states and can provide you with a referral for a naltrexone consult to get started. When you join Thrive, we’ll connect you with a specialized doctor who focuses on prescribing naltrexone and helping patients get started with confidence. These doctors are experienced in tailoring the treatment to minimize side effects, ensuring a smooth and supportive start to your journey.
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- While topiramate is not FDA-approved for alcohol-use disorder, studies have suggested that it can reduce alcohol cravings and withdrawal symptoms.
- According to Dr. David Sinclair, if you continue drinking, you must always take naltrexone beforehand to prevent relapse.
- But since naltrexone blocks alcohol’s pleasurable effects, the desire to drink decreases.
- In the 1980s he proposed that alcohol consumption (including problematic overuse) was learned behavior, reinforced by an endorphin release in the brain, and could therefore be unlearned.
- This differs from conventional AUD treatments, which promote total abstinence from the very beginning of starting treatment.
A slip https://ecosoberhouse.com/ may involve forgetting to take naltrexone before drinking or drinking more than intended on one occasion. The Sinclair Method is a treatment for alcohol use disorder that involves the use of naltrexone to reduce the brain’s association between alcohol and pleasure. While topiramate is not FDA-approved for alcohol-use disorder, studies have suggested that it can reduce alcohol cravings and withdrawal symptoms. In fact, the American Psychiatric Association recommends it as an option for moderate to severe AUD, including for people who haven’t had success with naltrexone or acamprosate. Several studies have found that acamprosate effectively helps people reduce alcohol use, even after the medication is stopped.
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Additionally, if someone chooses to continue drinking while on naltrexone, they can drink enough to break the protective “wall” that naltrexone provides. As a result, the enjoyment or “buzz” that alcohol provides can come back, which can lead to a return of previous levels of use. The most important rule of the Sinclair Method is consistency in taking the medication.

The Sinclair Method (TSM) is an evidence-based treatment for alcohol addiction that was developed by Dr. John David Sinclair, a researcher who dedicated his career to studying the effects of alcohol on the brain. Unlike traditional methods that advocate complete abstinence, the Sinclair Method focuses on pharmacological extinction, which involves the use of medication to break the cycle of addiction. Research suggests that it can be very effective in helping people reduce their drinking. According to Sinclair’s research, the use of naltrexone to treat alcohol use disorder can have a 78% efficacy rate. While some people feel an immediate reduction in alcohol cravings after their first time drinking on naltrexone, it’s usually a gradual process that can take anywhere from a few months to a year.
How Is Alcohol Withdrawal Treated in a Hospital Setting?
✔ Safe and non-addictive – Unlike some other treatments, naltrexone itself is not habit-forming. ✔ Affordable and accessible – Naltrexone is a generic medication, making it a cost-effective option. Addiction is a primary, chronic disease of brain reward, motivation, memory and related circuitry. Dysfunction in these circuits leads to characteristic biological, psychological, social and spiritual manifestations. This is reflected in an individual pathologically pursuing reward and/or relief by substance use and Sober living house other behaviors. The medication doesn’t activate the euphoric feeling caused by addictive drugs.
- For instance, CBT might help identify maladaptive beliefs (“I can’t cope with stress without alcohol”) and reframe them.
- Now that you can answer the question, What is The Sinclair Method for alcoholism?
- It’s important to consult with a healthcare professional to determine if TSM is appropriate for your situation.
- The goal is to gradually lose interest in alcohol over time, leading to complete abandonment of drinking habits.
- If you are interested in starting the Sinclair Method, consult your healthcare professional to determine if they are comfortable prescribing naltrexone to you or if they will refer you to someone who is.
In this article, you’ll learn how the Sinclair Method works, how successful the Sinclair Method is, and what other alternative treatments are available to you. Based on the results, additional labs can be ordered every 3 to 6 months. More frequent monitoring may be necessary if there is liver damage or other medical concern. Naltrexone is generally well-tolerated, but like all medications, it has the potential what is the sinclair method to cause side effects.
